|Proteomic studies into the ubiquitin system
|Date Posted||Monday, 15 October 2012|
MRC Laboratory of Molecular Biology
Cambridge, CB2 0QH
|Job Description||Applications are invited to join the team of David Komander at MRC LMB to establish mass-spectrometry techniques relating to protein ubiquitination in the Komander lab. Different types of ubiquitin signals regulate diverse cellular functions, however the roles of atypical ubiquitin chains has remained poorly studied (Kulathu and Komander, Nat Rev Mol Cell Biol (2012)). Our recent work has generated a plethora of tools and reagents with which binding partners and substrates of atypical ubiquitin chains can be identified. This will reveal new functions of these unstudied posttranslational modifications. The work will be performed using a dedicated Q-Exactive mass spectrometer.|
|Qualification||You have a PhD and significant expertise in mass spectrometry ranging from experimental design, sample preparation, instrument operation, maintenance and troubleshooting, data acquisition, and data analysis.
Experience with SILAC and AQUA techniques, as well as operating OrbiTrap / Q-Exactive instruments is an advantage. In addition, you show a keen interest in cellular regulation, and have contributed significantly to high-profile publications. You have the ability to establish new techniques independently, and develop specific application protocols. You are comfortable working with and educating a small, dedicated team of scientists at all levels (from PhD student to PI), and to drive independent research projects as well as contribute to ongoing projects in the Komander lab. You will be responsible for efficient and smooth running of mass-spectrometry within the Komander lab.
|How to Apply||Applications should be submitted via http://www.topcareer.jobs|
|Application deadline||18 Nov 2012|
|Supervisor/ Principal Investigator||David Komander|
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