|Roles of deubiquitinases in cellular regulation
|Date Posted||Monday, 15 October 2012|
MRC Laboratory of Molecular Biology
Cambridge, CB2 0QH
|Job Description||Applications are invited to join the team of David Komander at MRC LMB to study the roles of deubiquitinating enzymes in cellular regulation. Different types of ubiquitin signals regulate diverse cellular functions, however the roles of atypical ubiquitin chains have remained poorly studied (Kulathu and Komander, Nat Rev Mol Cell Biol (2012)). We recently discovered OTU domain deubiquitinases that selectively target atypical ubiquitin chains. Functional characterisation of OTU deubiquitinases will reveal new roles for atypical ubiquitin chains.
The MRC Laboratory of Molecular Biology provides a highly collaborative environment of excellence, and has a strong track record in training postdoctoral fellows who have gone on to become leading scientists.
|Qualification||You have recently completed your PhD in cell signaling, and have used various state-of-the-art methods to interrogate protein function and posttranslational modifications in mammalian cells. A strong publication record with at least one first author paper in a high profile journal, and high motivation and excitement about science are essential. Insights into the ubiquitin system or experience with animal systems are an advantage.|
|How to Apply||Applications should be submitted via http://www.topcareer.jobs|
|Application deadline||18 Nov 2012|
|Supervisor/ Principal Investigator||David Komander|
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