|Date Posted||Monday, 15 October 2012|
Institute of Biomedicine
|Job Description||PhD student positions are available in the Laboratory of Cancer Biology of the Faculty of Medicine of the University of Tartu headed by Tambet Teesalu, Ph.D. The laboratory is established in the biomedical campus of the University of Tartu with support of an EMBO Installation Grant, Wellcome Trust Senior Research Fellowship and a European Research Council Starting Grant.
The mission of the Laboratory of Cancer Biology is to develop smart cancer therapeutics with increased potency and decreased side effects. We use phage display screens to identify homing peptides that bind to specific targets in the vasculature. Corresponding synthetic peptides are explored for targeting drugs and biologicals into tumors to increase their therapeutic index. Our scope includes understanding the molecular interactions involved to drive specificity and activity, focusing on Tumor Penetrating Peptides (TPP) that trigger bulk extravascular transport in the tumor tissue. The work will be carried out in close collaboration with the laboratories of Drs. E. Ruoslahti and K.N. Sugahara at the Cancer Center of the Sanford-Burnham Medical Research Institute in La Jolla, California (USA).
We look for highly motivated team players that want to be a part of an interdisciplinary, dynamic and translationally-oriented research lab.
Several research projects are available. Examples are development of novel TPP using in vivo phage display, mechanistic studies on cell and tissue penetration pathway of TPP, and development of long circulating tumor-homing nanoparticles for imaging and drug delivery.
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|Qualification||Candidates should hold a M.Sc. in biology, medicine, chemistry, or related fields (bioengineering, bio-nanotechnology). In addition to ability of creative thinking you must be an avid learner and passionate about developing in-depth understanding of cancer biology and new targeted cancer therapies.|
|How to Apply||Please send a cover letter briefly summarizing research interests and career goals and CV to Tambet Teesalu (Tambet.Teesalu@gmail.com).|
|Application deadline||March 2013|
|Supervisor/ Principal Investigator||Tambet Teesalu|
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