|Postdoctoral positions: Ubiquitin, SUMO and genome stability
|Date Posted||Sunday, 14 October 2012|
Institute of Molecular Biology (IMB)
|Job Description||Our lab studies the functions of the small posttranslational modifiers ubiquitin and SUMO in the maintenance of genome stability.
We are particularly interested in the mechanisms that allow cells to deal with DNA damage during replication. In a process called damage bypass, the replication machinery is enabled to “skip” over lesions in the template DNA. By acting as a major mechanism for the conversion of lesions into mutations, this pathway not only promotes survival in the presence of DNA damage, but it is also a potential source of genome instability in itself. The double-edged nature of damage bypass implies that a tight regulation of the pathway is essential for maintaining genome stability.
Using a combination of molecular and cellular biology, classical genetics and protein biochemistry, we are investigating the consequences of ubiquitin and SUMO conjugation for the efficiency and accuracy of damage bypass, the fidelity of the reaction, the influence of chromatin dynamics and the enzymatic machinery involved in the pathway. Our model systems include budding yeast, mammalian cell culture and Xenopus laevis egg extracts. Further information about our research is available at: www.imb-mainz.de/research/ulrich
|Qualification||We are looking for highly motivated candidates with a PhD in Molecular Biology, Cell Biology, Biochemistry or a related discipline. Applicants should be fluent in written and spoken English and have at least one first-author publication in an international, peer-reviewed journal. Experience in molecular biology techniques or protein biochemistry is required. A good background in yeast genetics would also be a plus.
We offer the possibility to work in an international, stimulating research environment in a newly founded Centre of Excellence in the Life Sciences, a competitive salary, and opportunities for career development and advanced training in cutting-edge methodology.
|How to Apply||Please direct all enquiries directly to Prof. Helle Ulrich.|
|Application deadline||15. January, 2013|
|Supervisor/ Principal Investigator||Helle Ulrich, PhD|
Prof. Helle Ulrich
Contact Phone: 0044-1707-625821
Contact Email: firstname.lastname@example.org
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