|PhD Positions: Ubiquitin, SUMO and genome stability
|Date Posted||Sunday, 14 October 2012|
Institute of Molecular Biology (IMB)
|Job Description||Our lab studies the functions of the small posttranslational modifiers ubiquitin and SUMO in the maintenance of genome stability.
We are particularly interested in the mechanisms that allow cells to deal with DNA damage during replication. In a process called damage bypass, the replication machinery is enabled to “skip” over lesions in the template DNA. By acting as a major mechanism for the conversion of lesions into mutations, this pathway not only promotes survival in the presence of DNA damage, but it is also a potential source of genome instability in itself. The double-edged nature of damage bypass implies that a tight regulation of the pathway is essential for maintaining genome stability.
Using a combination of molecular and cellular biology, classical genetics and protein biochemistry, we are investigating the consequences of ubiquitin and SUMO conjugation for the efficiency and accuracy of damage bypass, the fidelity of the reaction, the influence of chromatin dynamics and the enzymatic machinery involved in the pathway. Our model systems include budding yeast, mammalian cell culture and Xenopus laevis egg extracts. Further information about our research is available at: www.imb-mainz.de/research/ulrich
We offer a thorough scientific training in the context of a multinational team within a generously funded research institution. Students will be part of the International PhD In addition to the lab-based research project, this programme offers courses in various scientific techniques and methods as well as "soft skills", such as scientific writing, presentation skills and research management. Information about the PhD programme is available at: www.imb-mainz.de//students/international-phd-programme/
|Qualification||We are looking for highly motivated students with a Masters or equivalent degree in Molecular Biology, Cell Biology, Biochemistry or Chemistry. Prior research experience in one of these disciplines is highly desirable. Candidates should be fluent in English.|
|How to Apply||Please apply through the web site of the International PhD Programme of the Institute of Molecular Biology (IMB), Mainz:
Informal enquiries can be directed to Helle Ulrich (firstname.lastname@example.org).
|Application deadline||13. January, 2013|
|Supervisor/ Principal Investigator||Helle Ulrich, PhD|
Prof. Helle Ulrich
Contact Phone: 0044-1707-625821
Contact Email: email@example.com
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