Spatial and temporal organization of the bacterial cytoskeleton – cell biologist
Date Posted Friday, 12 October 2012
Location Jouy-en-Josas (Paris) FRANCE
Institute Information INRA Jouy-en-Josas
UMR1319 Micalis
I.N.R.A., Domaine de Vilvert
Jouy-en-Josas Cedex, 78352
Website: http://www.international.inra.fr/
Job Description A Postdoctoral position funded by an ERC Grant is available in the ‘Bacterial Cytoskeleton and Bacterial Cell Morphogenesis’ lab headed by Dr. Rut Carballido-López (http://www.micalis.fr/micalis_eng/Poles-and-teams/Pole-Biosys/FICP-Noirot/Group-3-Carballido-Lopez) for a project in Bacterial Cell Morphogenesis. How is cell shape determined in bacteria? How do bacterial cells perceive and regulate their size and shape? Our research project combines powerful genetic, biochemical, genomic and systems biology approaches available in the model bacterium Bacillus subtilis with modern high-resolution light microscopic techniques to study the dynamics and mechanistic details of the two major determinants of cell shape in bacteria: the actin-like MreB cytoskeleton and cell wall assembly. We have recently identified dynamic discrete cortical patches as the main cellular structure containing MreB in bacteria and performed a quantitative analysis of their dynamics (Dominguez-Escobar et al. 2011, Science). The aim of this postdoctoral project is to further analyze the spatial and temporal organization of the MreB cytoskeleton and associated proteins by high-resolution microscopy. The postdoc will also help to develop a high-throughput screen using the in vivo localization and dynamics of MreB isoforms as readout.

We are a well-funded lab with international character that offers a dynamic and open atmosphere in which collaborations and initiative are welcomed. Our working language is English
Qualification We are seeking a highly motivated and dynamic postdoctoral fellow with a PhD and previous postdoctoral experience in cell biology and experience in relevant subject areas demonstrated by peer-reviewed first author publications. The candidate should have a strong background in cytoskeleton-based processes and/or advanced light microscopy techniques, and a high grade of independence in his/her work. Experience in image analysis/computing and/or biophysics/single-molecule analysis would be appreciated. Validated experience in microscopy-based or RNAi-based screens and/or quantitative systems biology and/or background in biophysics are also considered a real advantage. Prior experience in bacterial research is not required. A strong focus on producing high level research outputs and experience of working effectively on a collaborative basis are essential.
Compensation 2 611,49 to 3 116,19 EUR /month (before taxes) depending on the previous experience
How to Apply Submit a single PDF document containing an informal covering letter including your motivation and research interests, your CV, publications list and contact details for at least 2 references by email to Rut CARBALLIDO-LOPEZ at rut.carballido-lopez@jouy.inra.fr

**Please indicate the position you are applying to in the object of your email, and where/how you heard of it in the body of your message
Application deadline Applications will be reviewed as they come. Starting date is negotiable throughout 2013 and 2014
Supervisor/ Principal Investigator Rut CARBALLIDO-LOPEZ
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