Career Development Fellow
Date Posted Wednesday, 10 October 2012
Location MRC Clinical Sciences Centre, London, UK.
Institute Information MRC Clinical Sciences Centre
Imperial College London
Hammersmith Hospital, Du Cane Road
London, W12 0NN
Website: http://www.csc.mrc.ac.uk/Research/Groups/EPI/CellProliferation/
Job Description Career Development Fellow – 3 year fixed term position
Identification of novel regulators of senescence & reprogramming
£30,124 - £35,860 per annum inclusive of London weighting. London W12
Applications are invited for a 3-year postdoctoral research position within the Cell Proliferation Group at the MRC Clinical Sciences Centre in London. We are looking for a highly motivated post-doc interested in joining our friendly and international team. The successful candidate will have the opportunity to work on one of several open projects involving the identification and characterization of novel senescence regulators by combining genetic screenings and expression profiles of inducible systems of senescence. Specific projects include:
• Screens for identification of senescence regulators.
• Understanding the regulation and function of the senescence secretome.
• Identification of factors regulating reprogramming to iPSCs.
Our lab has previously taken advantage of similar approaches to identify a self-amplifying network involving the chemokine receptor CXCR2 and its ligands, such as IL-8, in senescence reinforcement (Acosta et al. 2008 Cell). Recently we demonstrated how senescence limits reprogramming to induced pluripotent stem cells (Banito et al. 2009 Genes Dev). We have also a long-standing interest on the INK4a/ARF and have identified different epigenetic mechanisms involved in its regulation, including Polycomb repressive complexes (Gil et al. 2004 Nat. Cell Biol), histone demethylases (Barradas et al. 2009 Genes Dev) and non-coding RNAs (Yap et al. 2010 Mol Cell). Our interest also spans to understanding pluripotency and reprogramming to iPSCs and its interface with senescence (Banito et al. 2010 EMBO Rep; O’Loghlen et al 2012 Cell Stem Cell)
Candidates should be highly motivated, committed and have clear career goals. Experience in senescence, cancer research or genetic screens would be useful, but is not essential. A strong background in molecular and cellular biology is required. Experience working with primary cells, familiarity with retroviral and lentiviral systems, previous work with RNAi, ESCs and reprogramming to iPSCs or with high content microscopy systems (such as InCell 2000) would be highly valued. All applicants should have a Ph.D. degree in life sciences or equivalent experience and at least one first-author publication published or in press. In return we offer a highly attractive benefits package including 30 days annual leave plus bank holidays and privilege days, competitive salary and final salary pension scheme along with an interest free season ticket loan. Final appointment will be subject to pre-employment screening.
The Clinical Sciences Centre, is directly funded by the Medical Research Council, and associated with Imperial College. The CSC provide excellent core facilities and support structures, including automated microscopy systems, next generation sequence and proteomics. The Cell Proliferation Group is part of the Epigenetics Section and interacts with other groups in the CSC studying cell cycle, cancer, and chromatin organization.
For informal enquiries regarding the please contact Jesús Gil via email (jesus.gil@csc.mrc.ac.uk)
Cell Proliferation Group page: http://www.csc.mrc.ac.uk/Research/Groups/EDC/CellProliferation/
Applications are handled by the RCUK Shared Services Centre; to apply please visit our job board at http://www.topcareer.jobs and upload your CV with covering letter. Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003, please quote reference number IRC68290.
Closing date: 6th November 2012.
Interviews: November 2012.
Compensation £30,124 - £35,860 per annum inclusive of London weighting
How to Apply Candidates should be highly motivated, committed and have clear career goals. Experience in senescence, cancer research or genetic screens would be useful, but is not essential. A strong background in molecular and cellular biology is required. Experience working with primary cells, familiarity with retroviral and lentiviral systems, previous work with RNAi, ESCs and reprogramming to iPSCs or with high content microscopy systems (such as InCell 2000) would be highly valued. All applicants should have a Ph.D. degree in life sciences or equivalent experience and at least one first-author publication published or in press.
Application deadline 6th November 2012
Supervisor/ Principal Investigator Jesus Gil
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