|Post-doc position in cell and developmental biology.
|Date Posted||Friday, 05 October 2012|
|Location||INSTITUTE OF BIOLOGY-VALROSE, NICE, FRANCE|
INSTITUTE OF BIOLOGY-VALROSE
Centre de Biochimie, UMR7277
|Job Description||Position available immediately in Pascal Thérond laboratory to functionally characterize Hedgehog secretion and spreading in Drosophila. Hedgehog proteins are key signaling mediators that govern a wide range of processes during embryonic development and adult tissue homeostasis from Drosophila to human. The Hedgehog proteins are the only metazoan proteins known to possess a covalently-linked cholesterol moiety. Hedgehog proteins can exert its effect at long distances, up to 300 micrometers in vertebrates. The project aims to gain insight into the secretion and the spread through tissue of the Hedgehog protein family using cell biology and genetic technics. Combination of genome-wide RNAi screen and in vivo imaging and tracking will be developped to investigate Hh mode of release and spreading.
Selected references: Gallet, et al., (2008), Dev. Cell 14, 1-14. Ayers et al., (2010) Dev. Cell 18, 605–620. Ranieri et al., (2012) Dev Cell 22, 279-294. Thérond (2012) Current Opinion in Cell Biology. 24 (2):173-180.
|Qualification||Knowledge of and experience in fly genetics, cell biology and optic microscopy are necessary. The position is funded for 2-3 years in duration. The candidates must have a Ph.D. degree, and can be nationals of any country.
|Compensation||29 000 to 36 000 euros/year.|
|How to Apply||Interested candidates should send a Curriculum Vitae and a list of three referees to:
Dr. Pascal Therond, CNRS-UMR 6543, Université de Nice-Valrose, 06108 Nice Cedex 2, France. Email: firstname.lastname@example.org
|Application deadline||Open position up to mai 2013|
|Supervisor/ Principal Investigator||Thérond Pascal|
Contact Phone: 33-492076446
Contact Email: email@example.com
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