| Caveolae in membrane tension and trafficking |
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| Date Posted | Thursday, 04 October 2012 |
| Location | Integrin Signalling Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), C/ Melchor Fernández Almagro, 3. Madrid, Spain, 28029 |
| Institute Information |
Centro Nacional de Investigaciones Cardiovasculares (CNIC) C/ Melchor Fernández Almagro 3 Madrid, 28029 Website: http://www.cnic.es/en/inflamacion/integrinas/index.php |
| Job Description | Our interest is in the mechanisms through which integrins, Rho/Rac GTPases and caveolae components (caveolins, cavins, membrane curvature proteins, etc) cooperate to regulate gene expression, cell cycle progression, migration, polarization, vesicle trafficking, cytoskeletal rearrangements and mechanotransduction, key processes in the pathogenesis of cancer and inflammatory and cardiovascular diseases. The project will study vesicle trafficking and cytosekeletal reorganization in response to mechanical cues, to unravel the molecular mechanisms by which the interplay between adhesion, mechanical tension and actin cytoskeleton regulate membrane trafficking; one particular aim will also study Rac1 nucleocytoplasmic shuttling and determine the importance of this GTPase in the structure and functionality of the nucleus. We are using a variety of molecular, cell biology and biochemistry tools, state-of-the-art quantitative live microscopy, image analysis SW, mass spec, mouse genetics, genome-wide approaches and bioinformatics tools.
Selected Recent Papers from the lab are: • Echarri et al. (2012) J Cell Sci 125:3097-3113. • Echarri and Del Pozo (2012) Curr Biol 22: R114 - R116 • Navarro-Lerida et al. (2012) EMBO J 31:534-551 • Goetz, et al. (2011) Cell 146: 148–163 • Muriel et al. (2011) J Cell Sci 124:2763-76. • Cerezo, et al. (2009) Mol and Cell Biol 29: 5046-5059 • Grande, et al. (2007). J Cell Biol 177: 683-694. Full productivity of the PI can be found in the following link: http://www.ncbi.nlm.nih.gov/pubmed?term=del%20pozo%20MA |
| Qualification | We are looking for an outstanding postdoctoral fellow with experience in the following areas:
i) State-of-the-art Live Microscopy, ii) Cell and Molecular Biology. iii) Cell-based image analysis software such as Matlab, Definiens, Cell Profiler, Image J, etc. iv) Additional expertise in mass spec, generation and handling of genetically engineered mice, and/or high content screening data mining and integration with machine learning classification algorithms will be positively evaluated. Exposure to data processing workflow applications such as KNIME is an asset. The candidate should bear a CV eligible for EMBO, Marie Curie of HFSP postdoctoral fellowships. |
| Compensation | We are looking for outstanding candidates to apply to competitive external funding |
| How to Apply | Please send by email to ebieger@cnic.es: a cover letter, a CV, a statement of research with a list of publications, as well as letters of recommendation from three referees |
| Application deadline | Continuous application, before postdoc fellowship calls |
| Supervisor/ Principal Investigator | Miguel Ángel del Pozo, MD, PhD |
| Contact Info |
Miguel Ángel del Pozo Contact Phone: +34-914531200 Contact Email: ebieger@cnic.es |
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