|Postdoctoral Research Fellow
|Date Posted||Monday, 17 September 2012|
Cancer Research UK London Research Institute
44 Lincoln's Inn Fields
London, WC2A 3LY
|Job Description||The Apoptosis and Proliferation Control Laboratory at the Cancer Research UK London Research institute is investigating the control of tissue size in Drosophila melanogaster. The Hippo pathway has emerged in recent years as a major determinant of tissue size and has been implicated as a tumour-suppressor pathway in mammals. Our research is focused on elucidating the mechanisms that regulate Hippo signalling during development and in adult stem cells. We use a combination of Drosophila genetics, state-of-the-art imaging, biochemistry and computational biology. We are seeking an ambitious postdoctoral fellow to join our multi-disciplinary research programme. Candidates should have training in fly genetics and molecular/cell biology techniques.
The Cancer Research UK London Research Institute (formerly known as ICRF), situated in central London, is one of the top cancer research institutes worldwide. It offers exceptional core facilities and a varied research portfolio.
1. Mao, Y., Tournier, A.L., Bates, P.A., Gale, J.E., Tapon, N., and Thompson, B.J. (2011). Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila. Genes Dev 25, 131-136.
2. Genevet, A., and Tapon, N. (2011). The Hippo pathway and apico-basal cell polarity. Biochem J 436, 213-224.
3. Shaw, R.L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B.A., and Tapon, N. (2010). The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 137, 4147-4158.
4. Ribeiro, P.S., Josue, F., Wepf, A., Wehr, M.C., Rinner, O., Kelly, G., Tapon, N., and Gstaiger, M. (2010). Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol Cell 39, 521-534.
5. Genevet, A., Wehr, M.C., Brain, R., Thompson, B.J., and Tapon, N. (2010). Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell 18, 300-308.
6. Langton, P.F., Colombani, J., Chan, E.H., Wepf, A., Gstaiger, M., and Tapon, N. (2009). The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis. Curr Biol 19, 1969-1978.
|Compensation||c.£31.500 per annum|
|How to Apply||Contact Dr Nic Tapon (firstname.lastname@example.org)|
|Supervisor/ Principal Investigator||Dr Nic Tapon|
Contact Email: email@example.com
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