|Postdoctoral Research Fellow
|Date Posted||Monday, 17 September 2012|
Cancer Research UK London Research Institute
44 Lincoln's Inn Fields
London, WC2A 3LY
|Job Description||The mammalian RASSF (Ras association domain) family is comprised of 10 members characterized by the RA (Ras Association) domain, which mediates association to Ras GTPases. Most members of the RASSF family have been linked with tumourigenesis and in particular several family members have been reported to regulate the Hippo tumour suppressor pathway, a major determinant of tissue size in flies and mammals.
Our lab has been studying the molecular function of the RASSF proteins in Drosophila melanogaster for a number of years, showing their involvement in the dynamics of cell-cell contacts (Langton, PF et al, Curr Biol, 2009) as well as modulation of the Hippo pathway via the PP2A phosphatase (Polesello, C et al Curr Biol 2006; Ribeiro, PS et al, Mol Cell 2010). We seek an outstanding mouse geneticist to join our team in order to extend our finding into mouse models for RASSF family members, some of which have already been generated in the lab. We are particularly interested in the role of these proteins in growth control and tissue architecture during development and tumour formation and experience in these areas would be an asset.
The Cancer Research UK London Research Institute is situated in central London and offers an outstanding research environment, with access to state-of-the-art facilities such as histopathology, transgenics, intravital imaging, mass spectrometry etc…
|Compensation||c.£31.500 per annum|
|How to Apply||Contact Dr Nic Tapon (email@example.com)|
|Supervisor/ Principal Investigator||Dr Nic Tapon|
Contact Email: firstname.lastname@example.org
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