| PhD Student |
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| Date Posted | Wednesday, 05 September 2012 |
| Location | CNIO; Madrid, Spain |
| Institute Information |
CNIO Melchor Fernandez Almagro, 3 Madrid, 28029 Website: http://www.hhmi.org/research/iecs/fernandez-capetillo.html |
| Job Description | DNA damage is the source of mutations that initiate cancer. In addition, we now know that the gradual accumulation of DNA damage, particularly when it occurs in stem cells, is largely responsible for the decline of tissue regeneration capabilities that are associated with aging. In this context, a significant focus of recent biomedical research has been dedicated to understanding how cells repair and respond to DNA damage. As a result, we now have a reasonably good understanding of the molecular mechanisms that safeguard genomic integrity. However, an important question that remains to be resolved is which one(s) is/are the key source of endogenous DNA damage that limits our lifespan. Eroded telomeres, reactive oxygen species, chromosome breaks—all have been postulated as the source of endogenous damage that is responsible for aging. Still, no definitive answer is available about the primary source of DNA damage that drives aging in living organisms. Within this arena, my laboratory investigates the impact of a different kind of genomic insult, which is linked to DNA replication and therefore inherent to life, and which is widely known as replicative stress (RS).
The candidate will join our group as part of an International Marie Curie Training Network focused on DNA Repair Studies. Keywords from our group are: cancer, ageing, mouse models, drug design, high-throughput microscopy, DNA damage. For a broader view of our group visit our webpages at: 1. CNIO: http://www.cnio.es/ing/grupos/plantillas/presentacion.asp?grupo=50004266 2. HHMI: http://www.hhmi.org/research/iecs/fernandez-capetillo.html Note: The candidate could potentially join the group at anytime between October 2012 to October 2013, but I would prefer a date well into 2013. |
| Qualification | M.Sc. on Life Sciences |
| How to Apply | E-mail to ofernandez@cnio.es including:
1. CV 2. Name of 2 referees. 3. Letter of motivation. |
| Application deadline | Open call that ends in Oct 2013 |
| Supervisor/ Principal Investigator | Oscar Fernandez-Capetillo |
| Contact Info |
Oskar Contact Email: ofernandez@cnio.es |
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